Demographic, genetic, and pathological correlates of Cerebral Amyloid
Angiopathy
 
   Lead Investigator:    John Ringman
   Institution      :    EASTON CENTER FOR ALZHEIMER'S DISEASE Research at
   E-Mail           :    john.ringman@med.usc.edu
   Proposal ID      :    431


   Publications:


1  Ringman J,  Monsell S , Nguyen A, Tung S, Zhou Y, Ng D, Vinters H
   Prevalence of cerebral amyloid angiopathy on autopsy in autosomal dominant Alzheimer's disease
   Abstract  Neurology,84:S33.008,2015,

   PUBLISHED



2  Ringman JM,  Monsell S , Ng DW, Zhou Y, Nguyen A, Coppola G, Van Berlo V, Mendez MF, Tung S, Weintraub S, Mesulam MM, Bigio EH, Gitelman DR, Fisher-Hubbard AO, Albin RL, Vinters HV
   Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database
   Journal Article  J Neuropathol Exp Neurol,75:284-290,2016,PMC4934612

   PUBLISHED





   Proposal Description:
   With this data query, we hope to address the following specific aims:                                                                                    1) Verify if CAA is more common in Hispanics                                                                                                                        2) Establish whether it is the case in Mexicans, Puerto Ricans, Central Americans, and/or South Americans                                                                                                                                   3) Determine if the nature and correlates of CAA differ among those with different APOE genotypes or PSEN1, PSEN2, or APP mutations.                                                                                                         4) Compare age of onset of cognitive symptoms, duration of illness, and age at death in Hispanics with CAA vs. non-Hispanics with CAA                                                                                                              5) Determine the relationship of CAA and other aspects of AD pathology overall and if this differs with regard to APOE genotype.